Answer case study

1. By which route would the β-blocker, the prostaglandin analogue and muscarinic agonist be administered in the treatment of TH’s glaucoma? Why? (2 marks)
2. Explain how each of the drug groups used to treat her glaucoma relieve the high intraocular pressure. You must cover the pharmacological mechanisms. (6 marks)

3. How can systemic absorption of these drugs be minimised? (2 marks)
4. What are the common local adverse reactions associated with topical administration of eye drops? (2 marks)
5. Given PB’s pre-existing health problems, are there likely to be any precautions associated with her prescribed glaucoma therapy? (2 marks)

6. Are there any potential drug interactions between her existing therapy and her glaucoma therapy worth noting? (2 marks)

7. What changes to eye structures are associated with prostaglandin analogue therapy? Are these changes harmful to the eye? (2 marks)
8. What advice would you give her regarding the adverse effects she might expect when using the β-blocker and the muscarinic agonist? (2 marks)