Medicinal chemistry

Topic: Medicinal chemistry

Order type: Essay
Write a Pre-lab experiment of THE SYNTHESIS OF 5-(DIMETHYLAMINO)METHYL-2-FURANMETHANETHIOL, A PRECURSOR OF RANITIDINE (ZANTACTM), A COMPETITIVE HISTAMINE H2 BLOCKER ……

The following are the questions to research and answer,
PRE-LAB EXERCISE

1. Explain why ranitidine (ZantacTM) is pharmacologically superior to cimetidine (TagametTM), but has a tolerability profile inferior to famotidine or nizatidine. Under what circumstances should ranitidine be used with caution?

2. Compare and contrast the administration of ranitidine (ZantacTM) by intravenous infusion in relation to other methods of drug administration. What measures should be taken to reduce microbial contamination of pharmaceuticals given in this way?

3. Explain why H2 receptor antagonists are different to Proton Pump Inhibitors (PPIs). PPIs have ostensibly the same mode of action, however are there any other ways that they can be differentiated from each other?

4. Using no more than a 1000 words describe the processes involved in progressing a fully tested generic pharmaceutical from the laboratory to the market place as a proprietary medicine.

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